Distinct Chemistries Define the Diverse Biological Effects of Plasma Activated Water Generated with Spark and Glow Plasma Discharges

The spread of multidrug-resistant bacteria poses a significant threat to human health. Plasma activated liquids (PAL) could be promising alternative for microbial decontamination, where different PAL can possess diverse antimicrobial efficacies and cytotoxic profiles, depending on the range concentration their reactive chemical species. In this research, biological activity plasma water (PAW) targets including both microbiological mammalian cells was investigated in vitro. aim further an understanding specific role distinct species, which is required tailor use applications high without adversely affecting biology eukaryotic cells. PAW generated by glow spark discharges, provide selective generation hydrogen peroxide, nitrite nitrate liquid. made either or discharges showed similar efficacy stability activity, despite very oxygen species (ROS) nitrogen profiles (RNS). However, trends were observed activities effects enzyme function, translated through generation. These findings indicate mechanisms action may exploited when tailoring various applications. A remarkable heat pressure noted with set up, broadens application potential. features also suggest that post modifications harnessed as means modulating chemistry, mode delivery functionalised liquids. Overall, these results how tuned candidate disinfectant agents biomedical bio-decontamination areas.